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Literature summary extracted from

  • Mosammaparast, N.; Kim, H.; Laurent, B.; Zhao, Y.; Lim, H.J.; Majid, M.C.; Dango, S.; Luo, Y.; Hempel, K.; Sowa, M.E.; Gygi, S.P.; Steen, H.; Harper, J.W.; Yankner, B.; Shi, Y.
    The histone demethylase LSD1/KDM1A promotes the DNA damage response (2013), J. Cell Biol., 203, 457-470.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.99.66 additional information H3K4me2 demethylation marks sites of DNA damage and occurs primarily in late S/G2 Homo sapiens
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1.14.99.66 nucleus association of LSD1 with sites of DNA damage, immunohistochemic localization, overview Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.66 histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
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 histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.66 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.66 U2-OS cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.66 histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
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 Homo sapiens histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.66 histone demethylase
-
 Homo sapiens
1.14.99.66 LSD1
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 Homo sapiens
1.14.99.66 LSD1/KDM1A
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 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.99.66 additional information LSD1 recruitment to sites of DNA damage is dependent on E3 ligase RNF168, RNF168 interacts with LSD1, overview. Rapid, transient recruitment of RNF168 to damage sites is H2A.X independent Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.99.66 malfunction loss of LSD1 causes gamma-irradiation hypersensitivity and increased homologous recombination Homo sapiens
1.14.99.66 physiological function H3K4me2 demethylation marks sites of DNA damage and is cell cycle and LSD1 dependent. LSD1 recruitment to sites of DNA damage is dependent on E3 ligase RNF168, overview. LSD1 is recruited to sites of DNA damage but its retention is relatively transient. LSD1 promotes 53BP1 foci formation primarily in late S/G2 cells, and LSD1 promotes H2A/H2A.X ubiquitylation upon DNA damage Homo sapiens